Description
Buy Methylone Online
Methylone is the type of illicit drug in the market and is the best beta-keto-substituted analogues of the corresponding amphetamines. The metabolism of the Methylone was found in rats and was metabolized similarly to their methylenedioxy-substituted amphetamine analogues, namely by O-demethylenation followed by methylation of one of the hydroxy groups. We are one of the reputed and highly-rated Methylone suppliers in the region and you can rely on us to get the best product for medical & other uses.
Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x slower than that of MDMA. The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine. ShanghaiChemicals is the best Methylone supplier and also other kinds of chemicals for sale in an easy way.
Description
Methylone ((3,4-methylenedioxy)methcathinone) is a synthetic cathinone. It is the beta-keto version of 3,4-methylenedioxymethylamphetamine (mdma). It was originally developed as a therapeutic for Parkinson’s disease or depression by Shulgin. The use of methylone was first reported around 2005. The effects and the mode of use reported have similarities with MDMA, but its potency is less. Reported toxic effects of methylone include tachycardia, hypertension, paranoia, anxiety, bruxism, and muscle tension, and aching. Some of these effects leading to hospital admissions. Several analytically confirmed drug-related deaths have been reported.
Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. In comparison to MDMA, it has an approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar. However, methylone has relatively robust releasing capabilities, perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA. We are the Methylone supplier with the top characteristics and features.
Chemistry of Methylone
Methylone, also known as M1, 3, MDMC, or bk-MDMA, is an entactogen and stimulant of the phenethylamine, amphetamine, and cathinone classes. It is a completely new drug for most people. It is being referred to as one of the “second generation” of the new synthetic drugs. The chemical name of the methylone is 3,4-methylenedioxy-N-methylcathinone and its molecular formula C11H113NO3.
Its Abuse and Effects
Methylone has almost the same potency of MDMA, but it does not produce the same effects. The two major metabolic pathways in mammals for methylone are N-demethylation to methylenedioxycathinone (MDC), and demethylation followed by O-methylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC).
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