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1CP-LSD (1-cyclopropionyl-lysergic acid diethylamide) is a novel lysergamide with little to no history of use. It is said to be a less pushy and shorter-lasting version of LSD. Described as having a more gradual onset than 1P-LSD, with a less visual more meditative headspace when compared with LSD. It’s worth mentioning that 1cP-LSD was initially actually a side-product during the synthesis of another derivative, it was an unintended and serendipitous discovery.
1P-LSD is a psychedelic of the lysergamide class. 1P-LSD is forming the same family as LSD. Subjectively, 1P-LSD is similar to LSD and anecdotal reports often describe them as being identical. However, 1P-LSD is about 38% as potent as LSD.
Chemistry of ICP-LSD
The formal name is (6aR,9R)-4-(cyclopropanecarbonyl)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide and the molecular formula is C24H29N3O2.
LSD is unique among the classical psychedelics for its rich pharmacology. LSD has an affinity for a wide range of serotonin (5-HT1A, 5HT2A, 5-HT3) and dopamine receptor subtypes (D1). Its psychedelic effects are primarily due to agonism (activation) of the 5-HT2A receptor. Receptor binding studies of LSD bound to a human serotonin receptor have shown that the diethylamide of LSD produces a specific conformational change that causes the receptor to “fold in” onto itself and keep the LSD molecule trapped.
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Abuse and Its Effects
Lysergic acid diethylamide, commonly referred to as ‘acid’ or LSD, is a psychedelic hallucinogen that produces changes in perception, sense of time and space, and emotions. LSD is active at very small doses (around 20 micrograms). The drug is most commonly taken orally, in the form of tablets, droplets, or most commonly blotter paper that is absorbed on the tongue and swallowed.
It is important to know that taking too much LSD can lead to feelings of dissociation and alienation. Research indicates that for most individuals, 20 micrograms of LSD is so small that it provides minimal euphoric effects.
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